drug interaction with olysio

The following drugs are not recommended to be coadministered with OLYSIO^®

Anti-infectives

·                        Antibiotics (systemic administration)

·                                       Erythromycin,* clarithromycin, telithromycin

·                        Antifungals (systemic administration)

·                                       Itraconazole, ketoconazole, posaconazole, fluconazole, voriconazole

·                        Antimycobacterials

·                                       Rifampin,*^† rifabutin, rifapentine

HIV products

·                Cobicistat-containing product (elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate)

·                Efavirenz*

·                Other NNRTIs

·                               Delavirdine, etravirine, nevirapine

·                Darunavir/ritonavir*^‡

·                Other HIV products

·                               Atazanavir, fosamprenavir, lopinavir, indinavir, nelfinavir, saquinavir, tipranavir (boosted or unboosted), ritonavir*^§

Herbal products

·                        Milk thistle

·                        St. John's Wort

Cardiovascular agents

·                Amiodarone (coadministered with sofosbuvir)

·                 

Other drugs

·                        Anticonvulsants

·                                       Carbamazepine, oxcarbazepine, phenobarbital, phenytoin

·                        Dexamethasone (systemic)

·                        Cisapride

·                        Cyclosporine*^∥

The following requires caution and/or clinical monitoring when coadministered with OLYSIO^®

Cardiovascular agents

·                        ↑ Digoxin*

·                        Antiarrhythmics (oral administration) (↑ drugs)

·                                       Amiodarone (coadministered without sofosbuvir), disopyramide, flecainide, mexiletine, propafenone, quinidine

·                        Calcium channel blockers (oral administration) (↑ drugs)

·                                       Amlodipine, diltiazem, felodipine, nicardipine, nisoldipine, verapamil

·                        Statins (↑ drugs)

·                                       Pitavastatin, pravastatin, rosuvastatin,* atorvastatin,* simvastatin,* lovastatin

Immunosuppressants

·                ↑or↓sirolimus

Other drugs

·                Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension (↑ drugs)

·                               Sildenafil, tadalafil, vardenafil

·                Midazolam,* triazolam (↑ drugs; oral administration)

*These interactions have been studied in healthy adults with the recommended dose of OLYSIO^® 150 mg once daily unless otherwise noted.

^†The dose of OLYSIO^® in this interaction study was 200 mg once daily, both when given alone and when coadministered with rifampin 600 mg once daily.

^‡The dose of OLYSIO^® in this interaction study was 50 mg once daily when coadministered in combination with darunavir/ritonavir, compared with 150 mg once daily in the OLYSIO^®-alone treatment group.

^§The dose of OLYSIO^® in this interaction study was 200 mg once daily, both when given alone and when coadministered in combination with ritonavir 100 mg twice daily.

^∥Studied in combination with an investigational drug and RBV in a Phase 2 trial in HCV-infected post-liver transplant patients